Research
While Cissuslean® is primarily positioned for healthy weight and body-composition management, research has explored additional functional properties of its naturally occurring polyphenols, flavonoids and saponins.
Cissuslean® contains quercetin, isorhamnetin, luteolin, resveratrol and piceatannol. In a published rat OA model, a Cissus extract containing quercetin and isorhamnetin reduced markers associated with joint inflammation and supported cartilage integrity.
Human clinical evaluation at 300 mg/day in adults with knee osteoarthritis showed improvements in WOMAC pain, stiffness and physical function, alongside reductions in IL-6, MMP-3, leukotriene B4 and hs-CRP.
In the 12-week weight-management trial, participants showed favorable changes in total cholesterol, LDL, triglycerides, VLDL and HDL, complementing improvements in body-fat measures.
CT-measured visceral fat area decreased significantly in the active group versus placebo, alongside reductions in waist and hip circumference — outcomes relevant to abdominal-obesity strategies.
Adiponectin increased and leptin declined more substantially in the Cissuslean® group, suggesting favorable changes in adipose-tissue signalling associated with metabolic health.
DEXA analysis showed reductions in body fat mass and body-fat percentage while lean mass was maintained — a valuable property for body-composition and active-ageing formulations.
Some evidence remains preclinical or unpublished and should be interpreted accordingly. Detailed references are available in the scientific dossier on request.
