The Ingredient
Chemistry & Bioactives
Cissuslean® is a natural, standardized extract of Cissus quadrangularis L. developed to retain a broad spectrum of the plant’s naturally occurring phytochemicals — polyphenols, flavonoids, glycosides and saponins associated with weight-management, metabolic-health and joint-health applications.
The active compounds
Cissuslean® is particularly rich in the flavonoids quercetin and isorhamnetin. These compounds are supported by a wider phytochemical profile containing resveratrol, piceatannol, myricetin, quercitrin, luteolin, 3-O-rhamnopyranosylkaempferol and diosgenin.
Rather than isolating a single molecule, Cissuslean® preserves the full spectrum of the plant’s bioactives — a design choice that supports its multi-pathway activity across adipogenesis, lipid metabolism and inflammatory balance.
Phytochemical classes
Polyphenols
- Resveratrol
- Piceatannol
Stilbene polyphenols studied for antioxidant activity and metabolic support.
Flavonoids
- Quercetin
- Isorhamnetin
- Myricetin
- Quercitrin
- Luteolin
- 3-O-Rhamnopyranosylkaempferol
The dominant class in Cissuslean®, with quercetin and isorhamnetin as the principal characterised flavonoids.
Glycosides
- Genistein
- Daidzein
Naturally occurring glycosides associated with metabolic and bone health research.
Saponins
- Diosgenin
Plant saponin studied for its potential role in metabolic and inflammatory pathways.
Why full-spectrum matters
The characterised profile spans multiple structural classes. In cellular and animal research, these compounds have been associated with AMPK activation, PPARα upregulation, PPARγ and AKT downregulation, reduced ACC activity and modulation of NF-κB signalling — pathways relevant to fatty-acid oxidation, adipogenesis, lipid storage and inflammatory balance.
Retaining this diversity of compounds distinguishes Cissuslean® from single-molecule preparations and supports its dual positioning for healthy body composition and joint comfort.