Question 1

What is Cissuslean®?

Accepted Answer

Cissuslean® is a natural, standardized extract of Cissus quadrangularis, a medicinal plant native to India. It contains a characterised combination of polyphenols, flavonoids, glycosides and saponins and has been evaluated in preclinical and human clinical studies for weight management, body composition and joint health.

Question 2

What is Cissuslean® standardized to?

Accepted Answer

Cissuslean® is standardized through a defined phytochemical profile that includes quercetin, isorhamnetin and other naturally occurring bioactive compounds. Precise marker limits and analytical methods should be taken from the current approved product specification.

Question 3

How is Cissuslean® different from a generic Cissus extract?

Accepted Answer

Cissuslean® combines a defined phytochemical profile with product-specific preclinical research, human clinical evaluation and traceable manufacturing. Its evidence relates to the studied Cissuslean® formulation and cannot automatically be applied to other Cissus quadrangularis extracts. Cissuslean® is also the subject of patent applications in India, the United States and through the PCT route.

Question 4

Is Cissuslean® patented?

Accepted Answer

Patent applications covering Cissuslean® have been filed in India (No. 202641021756), through the PCT (PCT/IB2026/054903) and in the United States (No. 19/716,179). These are patent applications, not granted patents.

Question 5

What is the clinically studied dose of Cissuslean®?

Accepted Answer

A dose of 300 mg per day was evaluated in the Cissuslean® knee osteoarthritis study. The appropriate daily dose for weight-management applications should be confirmed from the final clinical protocol and approved technical dossier.

Question 6

How long does it take to work?

Accepted Answer

The weight-management trial assessed outcomes over 12 weeks (84 days). The joint-health study also evaluated changes over 84 days. Results may vary by individual, formulation, diet and lifestyle.

Question 7

What weight-management benefits have been studied?

Accepted Answer

The 12-week trial reported improvements in body fat mass and percentage, waist and hip circumference, visceral and subcutaneous fat, blood lipid profile, adiponectin and leptin, and overall body composition. 100 participants were randomised; the per-protocol analysis included 45 Cissuslean® and 41 placebo participants.

Question 8

What joint-health benefits have been studied?

Accepted Answer

In an 84-day randomised trial in adults with knee osteoarthritis, Cissuslean® was associated with a 44.96% reduction in WOMAC pain, 34.44% in stiffness, 48.01% improvement in daily activities, 45.66% reduction in total WOMAC and 21.29% reduction in VAS pain. Inflammatory and cartilage-related markers (IL-6, MMP-3, LTB4, hs-CRP) also improved.

Question 9

Is Cissuslean® safe?

Accepted Answer

Cissuslean® showed a favourable safety and tolerability profile in the 12-week weight-management study. Reported adverse events were mild, occurred across both groups and were considered unrelated to supplementation. No serious adverse events or clinically significant laboratory changes were reported.

Question 10

Is Cissuslean® GRAS?

Accepted Answer

The supplied materials do not establish a GRAS determination or FDA GRAS Notice number for Cissuslean®. This answer should be updated only after the applicable regulatory dossier is confirmed.

Question 11

Is Cissuslean® Non-GMO, Kosher, Halal, vegan or gluten-free?

Accepted Answer

Star Hi Herbs maintains Kosher and Halal certifications. Product-specific Non-GMO, vegan, gluten-free and allergen statements should be verified against the current Cissuslean® regulatory documentation before publication.

Question 12

Can Cissuslean® be used in capsules, tablets, powders, gummies or beverages?

Accepted Answer

Capsules, tablets and powder blends are the most straightforward applications. Gummies, beverages and other complex formats should be confirmed through formulation trials because stability, dispersibility, taste, processing temperature and final-product pH can affect performance.

Question 13

What use level should I formulate at?

Accepted Answer

For joint-health formulations, 300 mg per daily serving reflects the dose described in the clinical study. Weight-management use levels should be confirmed against the final clinical and technical dossier.

Question 14

What is the minimum order quantity?

Accepted Answer

The standard MOQ for Star Hi Herbs herbal extracts is 100 kg. Trial and commercial requirements can be discussed with the sales team.

Question 15

Can I request a sample?

Accepted Answer

Yes. Qualified product developers, manufacturers and brand owners can request a sample for evaluation. Please include the intended application, target market, required quantity and preferred finished-product format when submitting your request.

Question 16

Can I use the Cissuslean® logo on my finished product?

Accepted Answer

Customers may apply to use the Cissuslean® trademark subject to approval, a trademark licence agreement and compliance with the required product identity and use level.

Question 17

What is the shelf life?

Accepted Answer

Shelf life and storage conditions should be taken from the current specification sheet and batch-specific Certificate of Analysis. Store the material in its original sealed packaging under the conditions stated in the approved product documentation.

Frequently Asked Questions

Product

Dosage & efficacy

Safety & regulatory

Formulation

Commercial

Still have questions?